β-Glucuronidase-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

β-Glucuronidase-IN-1 是强效的，选择性，非竞争性和具有口服活性的 E. coli β-葡萄糖醛酸酶 (β-glucuronidase) 抑制剂，针对 E. coli β-葡萄糖醛酸酶的 IC50 和 Ki 值分别为 283 nM 和 164 nM。

β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibitingan IC50 and a Ki of 283 nM and 164 nM, respectively.

β-Glucuronidase-IN-1 (Inhibitor 1) (0.01-100 μM) inhibits E. coli?β-glucuronidase activity as a dose-dependent manner and exhibits an IC50 and a Ki value with 283 nM and 164 nM, respectively.β-Glucuronidase-IN-1 (100 μM; 24-72 hours) maintains potent efficacy in living bacterial cells (EC50=17.7 nM), it does not affect bacterial cell growth under aerobic or anaerobic conditions or killing mammalian epithelial cells. Cell Viability AssayCell Line:CMT93, CaCO-2, HCT116 cells Concentration:100 μM Incubation Time:24hours, 48 hours and 72 hours Result:Did not impact mammalian cell survival and any reduction in cell viability were attributed to the presence of DMSO.

β-Glucuronidase-IN-1 (oral gavage; 10 μg; twice per day; 11 days) protects the mouse GI epithelium from CPT-11–induced damage and protects the glandular structure of CPT-11-treated intestinal tissues.Animal Model:Healthy 6- to 8-week-old Balb/cJ mice Dosage:10 μg Administration:Oral gavage; twice per day; 11 daysResult:Alleviated CPT-11-induced toxicity in mice.

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GPCR/G Protein

Antibacterial

Antibacterial

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484006-66-8

425.54

C23H27N3O3S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (235.00 mM; 超声助溶 (<60°C)

CCOc1ccc(NC(=S)N(CCO)Cc2cc3cc(C)cc(C)c3[nH]c2=O)cc1

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(-20℃)

With Ice Pack

≥ 2 years