kb-NB142-70

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

kb-NB142-70 是一种有效的选择性 PKD 抑制剂，IC50 为 28.3 nM。

kb-NB142-70 is a potent and selective PKD inhibitor with IC50 of 28.3 nM; displays 10-fold increase in the in vitro PKD1 inhibitory potency versus CID755673; inhibits PC-3, PANC-1, CFPAC-1 cellular growth with IC50 of 5-30 uM.

kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also inhibits Ser916 phosphorylation of PKD1 (IC50, 2.2 ± 0.6 μM) in LNCaP cells. Moreover, kb NB 142-70 is cytotoxic against PC3 cells with an EC50 of 8.025 μM. kb NB 142-70 (0-5 μM) concentration-dependently prevents ANG II-induced phosphorylation of HDAC4 at Ser246 and Ser632, HDAC5 at Ser259 and Ser498, and HDAC7 at Ser155 in IEC-18 cells. In addition, kb NB 142-70 (3.5 μM) also suppresses HDAC4, HDAC5, and HDAC7 phosphorylation in IEC-18 cells stimulated with ANG II for 0-240 min or with vasopressin, lysophosphatidic acid (LPA), or phorbol 12,13-dibutyrate (PDBu).

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kb NB 142-70 | kb NB142-70 | kb NB-142-70

Apoptosis

PKD

PKD1|PKD2|PKD3

Cancer

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1233533-04-4

251.318

C11H9NO2S2

>98% (HPLC)

DMSO: 25.13 mg/mL (100 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

O=C1NCCSC2=C1SC3=CC=C(O)C=C32

3,4-dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one

(-20℃)

With Ice Pack

≥ 2 years