beta-Eudesmol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

β-Eudesmol 是烟碱型乙酰胆碱受体 (nAChR) 的非竞争性拮抗剂。它是一种倍半萜烯，已在包括大麻在内的多种植物中发现，并具有多种生物活性。

β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biological activities.

Western Blot Analysis Cell Line:HL-60Concentration:40 μM, 80 μM Incubation Time:4 h Result:Increased the expression of caspase-3 protein at 80 μM.Cell Viability Assay Cell Line:HL-60 Concentration:10 μM, 20 μM, 40 μM, 60 μM, 80 μM, 120 μM Incubation Time:4 h Result:Didn’t affect cell activity at a dose of 40 μM, but decreased cell activity at a dose of 80 μM, and cell viability decreased by 51.6%.Apoptosis Analysis Cell Line:HL-60 Concentration:40 μM, 80 μM Incubation Time:4 hResult:Had no effect on apoptosis at the dose of 40 μM, but induced apoptosis at the dose of 80 μM, and the apoptosis rate was 31.7%.

Animal Model:Male KM mice modelDosage:1.25 mg/kg, 2.5mg/kg, 5 mg/kg Administration:Intraperitoneal injection (i.p.); Once daily for 7 days Result:Inhibited the growth of H22 tumor cells with inhibition rates of 39.9% (2.5 mg/kg) and 49.3%(5 mg/kg), respectively.Inhibited the growth of S108 tumor cells with inhibition rates of 22.4% (2.5 mg/kg) and 42.2%(5 mg/kg), respectively.Significantly decreased vascular index with inhibition rates of 34.4% (2.5 mg/kg) and 44.3% (5 mg/kg).Animal Model: Male C57BL/6 mice model Dosage:50 mg/kg, 100 mg/kg Administration:Intraperitoneal injection (i.p.); Single dose. 2 h before the cecal ligation and puncture (CLP) operation. Result:Increased the expression of TNF-α, IL-1β and IL-6 in a dose-dependent manner.Increased the levels of superoxide dismutase (SOD) and glutathione (GSH), and decreased the levels of malondialdehyde (MDA) and myeloperoxidase (MPO).Inhibit the phosphorylation of p65.

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Others

Other Targets

nAChR| TRPA1| TRPV3| TRPM8

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473-15-4

222.37

C15H26O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (449.70 mM)

CC(C)(O)[C@@H]1CC[C@@]2(C)CCCC(=C)[C@@H]2C1

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(-20℃)

With Ice Pack

≥ 2 years