ZINC77292789

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是一种试剂，用于制备带有 βGalNAc-?Thr 的合成 MUC1 糖肽，作为 Tn 抗原异构体，诱导针对肿瘤细胞的抗体产生。 Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是制造基于三聚体 MUC1 免疫显性基序抗原的抗癌疫苗候选物的起始材料。

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH is a reagent for the preparation of a synthetic MUC1 Glycopeptide Bearing βGalNAc-?Thr as a Tn antigen isomer which induces the antibody production against tumor cells. Fmoc-Thr[GalNAc(Ac)3-α-D]-OH is a starting material to make trimeric MUC1 immunodominant motif antigen-?based anti-?cancer vaccine candidates.(In Vitro):The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn antigen).

The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome.

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Others

Other Targets

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116783-35-8

670.66

C33H38N2O13

>98% (HPLC)

In Vitro:?DMSO : ≥ 100 mg/mL (149.11 mM)

C[C@H]([C@@H](C(O)=O)NC(OCC1c(cccc2)c2-c2c1cccc2)=O)O[C@H]([C@@H]([C@H]1OC(C)=O)NC(C)=O)O[C@H](COC(C)=O)[C@@H]1OC(C)=O

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(-20℃)

With Ice Pack

≥ 2 years