
ZINC77292789
CAS No. 116783-35-8
ZINC77292789 ( —— )
产品货号. M29576 CAS No. 116783-35-8
Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是一种试剂,用于制备带有 βGalNAc-?Thr 的合成 MUC1 糖肽,作为 Tn 抗原异构体,诱导针对肿瘤细胞的抗体产生。 Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是制造基于三聚体 MUC1 免疫显性基序抗原的抗癌疫苗候选物的起始材料。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥543 | 有现货 |
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5MG | ¥883 | 有现货 |
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10MG | ¥1320 | 有现货 |
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25MG | ¥2211 | 有现货 |
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50MG | ¥3823 | 有现货 |
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100MG | ¥5468 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称ZINC77292789
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是一种试剂,用于制备带有 βGalNAc-?Thr 的合成 MUC1 糖肽,作为 Tn 抗原异构体,诱导针对肿瘤细胞的抗体产生。 Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是制造基于三聚体 MUC1 免疫显性基序抗原的抗癌疫苗候选物的起始材料。
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产品描述Fmoc-Thr[GalNAc(Ac)3-α-D]-OH is a reagent for the preparation of a synthetic MUC1 Glycopeptide Bearing βGalNAc-?Thr as a Tn antigen isomer which induces the antibody production against tumor cells. Fmoc-Thr[GalNAc(Ac)3-α-D]-OH is a starting material to make trimeric MUC1 immunodominant motif antigen-?based anti-?cancer vaccine candidates.(In Vitro):The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn antigen).
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体外实验The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number116783-35-8
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分子量670.66
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分子式C33H38N2O13
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : ≥ 100 mg/mL (149.11 mM)
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SMILESC[C@H]([C@@H](C(O)=O)NC(OCC1c(cccc2)c2-c2c1cccc2)=O)O[C@H]([C@@H]([C@H]1OC(C)=O)NC(C)=O)O[C@H](COC(C)=O)[C@@H]1OC(C)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册




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