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ZINC77292789

CAS No. 116783-35-8

ZINC77292789 ( —— )

产品货号. M29576 CAS No. 116783-35-8

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是一种试剂,用于制备带有 βGalNAc-?Thr 的合成 MUC1 糖肽,作为 Tn 抗原异构体,诱导针对肿瘤细胞的抗体产生。 Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是制造基于三聚体 MUC1 免疫显性基序抗原的抗癌疫苗候选物的起始材料。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥543 有现货
5MG ¥883 有现货
10MG ¥1320 有现货
25MG ¥2211 有现货
50MG ¥3823 有现货
100MG ¥5468 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    ZINC77292789
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是一种试剂,用于制备带有 βGalNAc-?Thr 的合成 MUC1 糖肽,作为 Tn 抗原异构体,诱导针对肿瘤细胞的抗体产生。 Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 是制造基于三聚体 MUC1 免疫显性基序抗原的抗癌疫苗候选物的起始材料。
  • 产品描述
    Fmoc-Thr[GalNAc(Ac)3-α-D]-OH is a reagent for the preparation of a synthetic MUC1 Glycopeptide Bearing βGalNAc-?Thr as a Tn antigen isomer which induces the antibody production against tumor cells. Fmoc-Thr[GalNAc(Ac)3-α-D]-OH is a starting material to make trimeric MUC1 immunodominant motif antigen-?based anti-?cancer vaccine candidates.(In Vitro):The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn antigen).
  • 体外实验
    The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome.
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ——
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    116783-35-8
  • 分子量
    670.66
  • 分子式
    C33H38N2O13
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : ≥ 100 mg/mL (149.11 mM)
  • SMILES
    C[C@H]([C@@H](C(O)=O)NC(OCC1c(cccc2)c2-c2c1cccc2)=O)O[C@H]([C@@H]([C@H]1OC(C)=O)NC(C)=O)O[C@H](COC(C)=O)[C@@H]1OC(C)=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

产品手册
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