
PF-05231023
CAS No. 1037589-69-7
PF-05231023 ( —— )
产品货号. M22505 CAS No. 1037589-69-7
PF-05231023 是一种长效成纤维细胞生长因子 21 (FGF21) 类似物,也是一种 FGF21 受体激动剂。它也适合作为 T2DM 的潜在治疗方法进行开发。 PF-05231023 是长效成纤维细胞生长因子 21 的类似物。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥356 | 有现货 |
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5MG | ¥616 | 有现货 |
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10MG | ¥988 | 有现货 |
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25MG | ¥1847 | 有现货 |
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50MG | ¥3013 | 有现货 |
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100MG | ¥4836 | 有现货 |
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200MG | ¥7266 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称PF-05231023
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述PF-05231023 是一种长效成纤维细胞生长因子 21 (FGF21) 类似物,也是一种 FGF21 受体激动剂。它也适合作为 T2DM 的潜在治疗方法进行开发。 PF-05231023 是长效成纤维细胞生长因子 21 的类似物。
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产品描述PF-05231023 is a long-acting fibroblast growth factor 21 (FGF21) analog and is an FGF21-receptor agonist. It is also suitable for development as a potential treatment for T2DM. PF-05231023 is a analog of long-acting fibroblast growth factor 21.PF-05231023 suppresses oxidative-stress-induced inflammation in photoreceptors. PF-05231023 decreases the variability of retinal NRF2 levels and displays a trend (non-significant) towards increased NRF2 levels in Akita mice. PF-05231023 decreases retinal IL-1β mRNA expression in Akita mice. PF-05231023 enhances cone-specific arrestin4 expression in Akita mice. PF-05231023 restores photoreceptor morphology in Akita mice. Administration of native FGF21 and PF-05231023 (3?mg/kg or 10?mg/kg; subcutaneously twice a week for two weeks) improves glucose tolerance and liver insulin sensitivity in Zucker rats. PF-05231023 (10 mg/kg; intraperitoneally injected) reduces retinal inflammation in diabetic mice.(In Vivo):Animal Model: Eight week old Zucker ratsDosage: 3?mg/kg and 10?mg/kg.Administration: Subcutaneously twice a week for two weeks.Result: There was no change of BW observed, and food intake was not changed in the treated groups compared to control. Caused a significant decrease of glucose excursion during the oral glucose tolerance test (OGTT) compared to control.
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体外实验——
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体内实验Animal Model:Eight week old Zucker rats Dosage:3?mg/kg and 10?mg/kg Administration:Subcutaneously twice a week for two weeksResult:There was no change of BW observed, and food intake was not changed in the treated groups compared to control. Caused a significant decrease of glucose excursion during the oral glucose tolerance test (OGTT) compared to control. Animal Model:7-to-8-month-old Akita mice with type 1 diabete model Dosage:10 mg/kg Administration:Intraperitoneally injected; twice a week; for four weeks Result:Administration improved retinal function in diabetic Akita mice.
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同义词——
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通路Others
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靶点Other Targets
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受体FGF21-receptor
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研究领域——
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适应症——
化学信息
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CAS Number1037589-69-7
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分子量528.55
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分子式C26H32N4O8
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纯度>98% (HPLC)
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溶解度DMSO:125 mg/mL (236.50 mM; Need ultrasonic)
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SMILESO=C(CCN1C(=O)C=CC1=O)NCCOCCOCCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Dong JQ, et al. Pharmacokinetics and pharmacodynamics of PF-05231023, a novel long-acting FGF21 mimetic, in a first-in-human study. Br J Clin Pharmacol. 2015 Nov;80(5):1051-63.
产品手册




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