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YM-1
CAS No. 409086-68-6
YM-1 ( YM1 )
产品货号. M14406 CAS No. 409086-68-6
YM-1 是 MTK-077 的紧密衍生物，以变构方式促进 Hsp70 与未折叠底物的结合，与 Hsp70 特异性结合，Kd 为 4.9 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称YM-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述YM-1 是 MTK-077 的紧密衍生物，以变构方式促进 Hsp70 与未折叠底物的结合，与 Hsp70 特异性结合，Kd 为 4.9 uM。
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产品描述YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM; enhances client protein ubiquitination and polyQ AR degradation; alleviates toxicity in a Drosophila model of spinobulbar muscular atrophy (SBMA); also disrupts the Hsp70-Bag3 interaction with IC50 of 5 uM.
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体外实验Western Blot Analysis Cell Line:HeLa and hTERT-RPE1 cell lines Concentration:10 μM Incubation Time:48 hoursI Result:Increased the level of p53 and p21 and decreased the level of FoxM1 and survivin.
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体内实验Animal Model:UAS-hAR52Q flies with polyQ AR-induced dihydrotestosterone (DHT) phenotypeDosage:1 mM Administration:Oral administration; 1 mM, for 7 days Result:Weakened the DHT-dependent eye degeneration phenotype and rescued DHT-dependent pupal toxicity of the polyQ AR.
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同义词YM1
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点HSP
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受体HSP
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研究领域——
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适应症——
化学信息
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CAS Number409086-68-6
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分子量417.97
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分子式C20H20ClN3OS2
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纯度>98% (HPLC)
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溶解度In Vitro:?H2O : 50 mg/mL (119.62 mM)
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SMILESCCN1C(=CC2=CC=CC=[N+]2C)SC(=C3N(C4=CC=CC=C4S3)C)C1=O.[Cl-]
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化学全称2-((Z)-((E)-3-Ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wang AM, et al. Nat Chem Biol. 2013 Feb;9(2):112-8.
2. Morishima Y, et al. Biochemistry. 2011 Aug 23;50(33):7146-56.
3. Colvin TA, et al. Cancer Res. 2014 Sep 1;74(17):4731-40.
