021-51111890
购物车（0）
sales@molnova.cn
XMD16-5
CAS No. 1345098-78-3
XMD16-5 ( XMD16-5 | XMD-16-5 | XMD 16-5 | XMD165 )
产品货号. M11379 CAS No. 1345098-78-3
XMD16-5 是一种有效的 Ack1 (TNK2) 抑制剂，ELISA 测定中 IC50 为 0.38 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥413 | 有现货 |
|
| 5MG | ￥745 | 有现货 |
|
| 10MG | ￥1191 | 有现货 |
|
| 25MG | ￥1920 | 有现货 |
|
| 50MG | ￥3540 | 有现货 |
|
| 100MG | ￥5249 | 有现货 |
|
| 500MG | ￥11178 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称XMD16-5
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述XMD16-5 是一种有效的 Ack1 (TNK2) 抑制剂，ELISA 测定中 IC50 为 0.38 uM。
-
产品描述XMD16-5 is a potent Ack1 (TNK2) inhibitor with IC50 of 0.38 uM in ELISA assay; exhibits potent inhibition of growth of the TNK2 mutant expressing cell lines with IC50s of 16 nM and 77 nM for the D163E and R806Q mutations.
-
体外实验XMD16-5 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD16-5 has IC50s of 16 nM and 77 nM for the D163E and R806Q mutations. The effects of XMD16-5 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD16-5.
-
体内实验——
-
同义词XMD16-5 | XMD-16-5 | XMD 16-5 | XMD165
-
通路Tyrosine Kinase
-
靶点Ack1 (TNK2)
-
受体TNK2
-
研究领域Cancer
-
适应症——
化学信息
-
CAS Number1345098-78-3
-
分子量416.47566
-
分子式C23H24N6O2
-
纯度>98% (HPLC)
-
溶解度DMSO: ≥ 29 mg/mL
-
SMILESOC(CC1)CCN1C(C=C2)=CC=C2NC3=NC=C4C(N(C)C(C=CC=C5)=C5C(N4)=O)=N3
-
化学全称6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-11-methyl-
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Miduturu CV, et al. Chem Biol. 2011 Jul 29;18(7):868-79.
2. Maxson JE, et al. Cancer Res. 2016 Jan 1;76(1):127-38.
