XL888 ( XL888; XL-888; XL 888 )

产品货号. M17840 CAS No. 1149705-71-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

XL888
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis.
产品描述

XL888 is an orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor XL888 specifically binds to Hsp90, inhibiting its chaperone function and promoting the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; inhibition of tumor cell proliferation may result. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins, including Her-2 and Met.
同义词

XL888; XL-888; XL 888
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

HSP90
研究领域

Cancer
适应症

——

CAS Number

1149705-71-4
分子量

503.6
分子式

C29H37N5O3
纯度

98%
溶解度

DMSO : ≥ 100 mg/mL; 198.55 mM
SMILES

CC[C@@H](C)Nc1c(cc(C)c(c1)C(=O)NC1CC2CCC(C1)N2c1ncc(cc1)C(=O)C1CC1)C(=O)N
化学全称

5-((R)-sec-butylamino)-N1-((1R,3s,5S)-8-(5-(cyclopropanecarbonyl)pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylterephthalamide

1.Taldone T,etal.Discovery and development of heat shock protein 90 inhibitors.Bioorg Med Chem. 2009 Mar 15;17(6):2225-35.

计算器

产品手册

关联产品

Lumateperone

Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM).
AVN-211

AVN-211 (CD-008-0173) is a novel and highly selective 5-HT6 receptor small molecule antagonist with Ki of 2.34 nM.
Quetiapine Fumarate

Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.