XEN-445 ( XEN445; XEN 445; XEN-445 )

产品货号. M17330 CAS No. 1515856-92-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

XEN-445
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
产品描述

XEN445 is potent and selective endothelial lipase inhibitor, that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. Endothelial lipase (EL) activity has been implicated in HDL metabolism and in atherosclerotic plaque development; inhibitors are proposed to be efficacious in the treatment of dyslipidemia related cardiovascular disease.
同义词

XEN445; XEN 445; XEN-445
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

endothelial lipase
研究领域

Cardiovascular Disease
适应症

——

CAS Number

1515856-92-4
分子量

366.33
分子式

C18H17F3N2O3
纯度

98%
溶解度

DMSO : ≥ 40 mg/mL. 109.19 mM
SMILES

c1(ccc(c(c1)C(=O)O)N1C[C@H](CC1)OCc1ncccc1)C(F)(F)F
化学全称

(S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid

1. Sun S, et al. Bioorg Med Chem. 2013, 21(24), 7724-7734.

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