XDM-CBP ( XDM CBP )

产品货号. M13410 CAS No. 2138461-99-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

XDM-CBP
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A highly potent and selective inhibitor of CBP/p300 bromodomain with Kd of 0.23/0.47 uM respectively.
产品描述

A highly potent and selective inhibitor of CBP/p300 bromodomain with Kd of 0.23/0.47 uM respectively, with high selectivity over all other BD families, including the BET family; exhibits antiproliferative effect on numerous cancer cell lines, in particular malignant melanoma, breast cancer, and leukemia (HL-60 and MCF-7 cells GI50=1.3 and 4.2 uM, respectively).
同义词

XDM CBP
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

2138461-99-9
分子量

366.42
分子式

C21H22N2O4
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(C1=C(CC)C(C(C)=O)=C(C)N1)NCC2=C3C(O)=CC=CC3=CC=C2O
化学全称

4-acetyl-N-((2,8-dihydroxynaphthalen-1-yl)methyl)-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide

1. Hügle M, et al. Angew Chem Int Ed Engl. 2017 Aug 2. doi: 10.1002/anie.201705516.

计算器

产品手册

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