• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

XCT790

CAS No. 725247-18-7

XCT790 ( XCT 790;XCT-790 )

产品货号. M15777 CAS No. 725247-18-7

A potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥478 有现货
10MG ¥794 有现货
25MG ¥1531 有现货
50MG ¥2795 有现货
100MG ¥4155 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    XCT790
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays.
  • 产品描述
    A potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays; shows no significant antagonist activity on related nuclear receptors (ERRγ or ERα, LXRα, LXRβ, FXR, PPARα, PPARδ, PPARγ, Nurr1, RARα, RORα, and RXRα) at 10 uM; inhibits PGC-1α regulation of ERRα and ERRα target gene expression; inhibits proliferation in cellular models of breast cancer.
  • 同义词
    XCT 790;XCT-790
  • 通路
    Endocrinology/Hormones
  • 靶点
    Estrogen Receptor/ERR
  • 受体
    ERRα
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    725247-18-7
  • 分子量
    596.42
  • 分子式
    C23H13F9N4O3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 21 mg/mL
  • SMILES
    O=C(NC1=NN=C(C(F)(F)F)S1)/C(C#N)=C/C2=CC=C(OCC3=CC=C(C(F)(F)F)C=C3C(F)(F)F)C(OC)=C2
  • 化学全称
    2-Propenamide, 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Willy PJ, et al. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8912-7.

2. Busch BB, et al. J Med Chem. 2004 Nov 4;47(23):5593-6.

3. Lanvin O, et al. J Biol Chem. 2007 Sep 28;282(39):28328-34.

4. Chang CY, et al. Cancer Cell. 2011 Oct 18;20(4):500-10.
产品手册
关联产品
  • 27-Hydroxycholestero...

    27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.

  • Liquiritigenin

    Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes

  • Isopsoralenoside

    Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.Psoralen (P), isopsoralen (IP), psoralenoside (PO) and Isopsoralenoside (IPO) are the major coumarins and coumarin-related benzofuran glycosides in Psoraleae Fructus, which have been reported to show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.