• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

WNT-974

CAS No. 1243244-14-5

WNT-974 ( LGK-974;LGK974;LGK 974;WNT 974;WNT974 )

产品货号. M10986 CAS No. 1243244-14-5

A potent and specific small-molecule Porcupine (PORCN) inhibitor with IC50 of 1 nM in the PORCN radioligand binding assay.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥478 有现货
5MG ¥786 有现货
10MG ¥1353 有现货
25MG ¥2584 有现货
50MG ¥4641 有现货
100MG ¥6634 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    WNT-974
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A potent and specific small-molecule Porcupine (PORCN) inhibitor with IC50 of 1 nM in the PORCN radioligand binding assay.
  • 产品描述
    A potent and specific small-molecule Porcupine (PORCN) inhibitor with IC50 of 1 nM in the PORCN radioligand binding assay; potently inhibits Wnt signaling with IC50 of 0.4 nM, with no major cytotoxicity; reduces Wnt-dependent LRP6 phosphorylation and the expression of Wnt target genes, such as AXIN2; is potent and efficacious in multiple tumor models at well-tolerated doses in vivo.Colon Cancer Phase 2 Clinical
  • 同义词
    LGK-974;LGK974;LGK 974;WNT 974;WNT974
  • 通路
    Wnt/Notch/Hedgehog
  • 靶点
    Porcupine
  • 受体
    Porcn
  • 研究领域
    Cancer
  • 适应症
    Colon Cancer

化学信息

  • CAS Number
    1243244-14-5
  • 分子量
    396.44
  • 分子式
    C23H20N6O
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: ≥ 32 mg/mL
  • SMILES
    O=C(NC1=NC=C(C2=NC=CN=C2)C=C1)CC3=CN=C(C4=CC(C)=NC=C4)C(C)=C3
  • 化学全称
    [2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Liu J, et al. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9.
2. Jiang X, et al. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12649-54.
3. Moon J, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654.
产品手册
关联产品
  • Clindamycin HCl

    Clindamycin Hydrochloride inhibits protein synthesis by acting on the 50S ribosomal.

  • Wnt-C59

    Wnt-C59(C59) is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.

  • IWP-O1

    IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM) effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.