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WNT-974
CAS No. 1243244-14-5
WNT-974 ( LGK-974;LGK974;LGK 974;WNT 974;WNT974 )
产品货号. M10986 CAS No. 1243244-14-5
A potent and specific small-molecule Porcupine (PORCN) inhibitor with IC50 of 1 nM in the PORCN radioligand binding assay.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥478 | 有现货 |
|
| 5MG | ￥786 | 有现货 |
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| 10MG | ￥1353 | 有现货 |
|
| 25MG | ￥2584 | 有现货 |
|
| 50MG | ￥4641 | 有现货 |
|
| 100MG | ￥6634 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称WNT-974
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent and specific small-molecule Porcupine (PORCN) inhibitor with IC50 of 1 nM in the PORCN radioligand binding assay.
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产品描述A potent and specific small-molecule Porcupine (PORCN) inhibitor with IC50 of 1 nM in the PORCN radioligand binding assay; potently inhibits Wnt signaling with IC50 of 0.4 nM, with no major cytotoxicity; reduces Wnt-dependent LRP6 phosphorylation and the expression of Wnt target genes, such as AXIN2; is potent and efficacious in multiple tumor models at well-tolerated doses in vivo.Colon Cancer Phase 2 Clinical
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同义词LGK-974;LGK974;LGK 974;WNT 974;WNT974
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通路Wnt/Notch/Hedgehog
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靶点Porcupine
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受体Porcn
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研究领域Cancer
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适应症Colon Cancer
化学信息
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CAS Number1243244-14-5
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分子量396.44
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分子式C23H20N6O
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 32 mg/mL
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SMILESO=C(NC1=NC=C(C2=NC=CN=C2)C=C1)CC3=CN=C(C4=CC(C)=NC=C4)C(C)=C3
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化学全称[2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Liu J, et al. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9.
2. Jiang X, et al. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12649-54.
3. Moon J, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654.
2. Jiang X, et al. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12649-54.
3. Moon J, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654.
产品手册
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