
WAY-600
CAS No. 1062159-35-6
WAY-600 ( WAY600 | WAY 600 | WAY600 )
产品货号. M17131 CAS No. 1062159-35-6
WAY-600 是一种有效的 ATP 竞争性选择性 mTOR 抑制剂,IC50 为 9 nM。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥786 | 有现货 |
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5MG | ¥1401 | 有现货 |
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10MG | ¥1936 | 有现货 |
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25MG | ¥3491 | 有现货 |
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50MG | ¥5168 | 有现货 |
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100MG | ¥7201 | 有现货 |
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500MG | ¥14823 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称WAY-600
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述WAY-600 是一种有效的 ATP 竞争性选择性 mTOR 抑制剂,IC50 为 9 nM。
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产品描述WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM.
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体外实验WAY-600 exhibits a concentration-dependent and time-dependent inhibition of f HepG2 and Huh-7 cells viability. Following WAY-600 (1-1000 nM) treatment, the number of HepG2 cell colonies is dramatically decreased. Meanwhile, BrdU incorporation in HepG2 cells is also inhibited with WAY-600 treatment. WAY-600 dose-dependently increases the activity of caspase-3 and caspase-9 in HepG2 cells. WAY-600 disrupts assemble of mTORC1 (mTOR-Raptor association) and mTORC2 (mTOR-Rictor association). Activation of mTORC1 (indicated by p-S6K1 and p-4E-BP1) and mTORC2 is almost blocked by WAY-600 (100 nM).
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体内实验Administration of WAY-600 (10 mg/kg, daily) inhibits HepG2 tumor growth in nude mice. Daily HepG2 tumor growth of WAY-600-administrated mice is significantly lower than that of vehicle control mice. Importantly, the in vivo anti-cancer activity by WAY-600 is further potentiated with the co-administration of MEK-162 (2.5 mg/kg, p.o. daily).
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同义词WAY600 | WAY 600 | WAY600
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通路Others
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靶点Other Targets
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受体mTOR| PI3Kα| PI3Kγ| Src| VEGFR2
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研究领域Cancer
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适应症——
化学信息
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CAS Number1062159-35-6
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分子量494.59
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分子式C28H30N8O
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纯度>98% (HPLC)
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溶解度DMSO : 50 mg/mL 101.09 mM;H2O : < 0.1 mg/mL
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SMILESC(N1CCC(CC1)N1N=CC2=C1N=C(N=C2N1CCOCC1)C1=CC2=C(NC=C2)C=C1)C1=CC=CN=C1
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化学全称4-(6-(1H-indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Yu K, et al, Cancer Res, 2009, 69(15), 6232-6240.