WAY-600

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

WAY-600 是一种有效的 ATP 竞争性选择性 mTOR 抑制剂，IC50 为 9 nM。

WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM.

WAY-600 exhibits a concentration-dependent and time-dependent inhibition of f HepG2 and Huh-7 cells viability. Following WAY-600 (1-1000 nM) treatment, the number of HepG2 cell colonies is dramatically decreased. Meanwhile, BrdU incorporation in HepG2 cells is also inhibited with WAY-600 treatment. WAY-600 dose-dependently increases the activity of caspase-3 and caspase-9 in HepG2 cells. WAY-600 disrupts assemble of mTORC1 (mTOR-Raptor association) and mTORC2 (mTOR-Rictor association). Activation of mTORC1 (indicated by p-S6K1 and p-4E-BP1) and mTORC2 is almost blocked by WAY-600 (100 nM).

Administration of WAY-600 (10 mg/kg, daily) inhibits HepG2 tumor growth in nude mice. Daily HepG2 tumor growth of WAY-600-administrated mice is significantly lower than that of vehicle control mice. Importantly, the in vivo anti-cancer activity by WAY-600 is further potentiated with the co-administration of MEK-162 (2.5 mg/kg, p.o. daily).

WAY600 | WAY 600 | WAY600

Others

Other Targets

mTOR| PI3Kα| PI3Kγ| Src| VEGFR2

Cancer

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1062159-35-6

494.59

C28H30N8O

>98% (HPLC)

DMSO : 50 mg/mL 101.09 mM;H2O : < 0.1 mg/mL

C(N1CCC(CC1)N1N=CC2=C1N=C(N=C2N1CCOCC1)C1=CC2=C(NC=C2)C=C1)C1=CC=CN=C1

4-(6-(1H-indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine

(-20℃)

With Ice Pack

≥ 2 years