Linarin ( Linarin )

产品货号. M18609 CAS No. 480-36-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Linarin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Linarin (acacetin-7-O-β-d-rutinoside) 对乙酰胆碱酯酶表现出选择性剂量依赖性抑制作用。
产品描述

Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediated apoptotic pathways. Linarin prevents A beta-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. The piperine significantly enhanced the oral absorption of Linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of Linarin.
体外实验

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体内实验

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同义词

Linarin
通路

Others
靶点

Other Targets
受体

TNF-α inhibitor
研究领域

Others-Field
适应症

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CAS Number

480-36-4
分子量

592.55
分子式

C28H32O14
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 250 mg/mL (421.91 mM)
SMILES

CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)OC)O)O)O)O)O)O)O
化学全称

7-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one