WAY-213613

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

WAY-213613 是一种有效的选择性 GLT-1/EAAT2 非底物再摄取抑制剂 (IC50: 85 nM EAAT2)。

WAY-213613 is a potent and selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 (IC50: 85 nM EAAT2). It displays 59- and 44-fold selectivity over EAAT1 and EAAT3 (IC50s: 5 and 3.8 μM, respectively). WAY-213613 shows no activity at ionotropic and metabotropic glutamate receptors.

WAY-213613 (0-100 μM) has inhibitory activity for human EAAT1, EAAT2 and EAAT3 subtype with IC50 values of 5004 nM, 85 nM and 3787 nM, respectively.WAY-213613 (3, 30, 300 nM) has the inhibitory effect on synaptosomal L-[3H] glutamate uptake with Ki values of 15 nM, 41 nM and 55 nM in the presence of 3, 30 and 300 nM, respectively.WAY-213613 (0-100 μM) produces a concentration-dependent block of glutamate-induced currents in EAAT1-, EAAT2- or EAAT3-injected oocytes, with IC50 values of 48, 0.13 and 4.0 μM, respectively.WAY-213613 (0.5–50 μM) exhibits good selectivity over ionotropic receptors and EAAT2 and potent activity toward blocking NMDA-stimulated responses.

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Others

Other Targets

EAAT2|EAAT3|EAAT1

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868359-05-1

415.19

C16H13BrF2N2O4

>98% (HPLC)

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N[C@@H](CC(Nc(cc1)ccc1Oc(cc(c(F)c1)F)c1Br)=O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years