Valemetostat ( —— )

产品货号. M21864 CAS No. 1809336-39-7

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

Valemetostat
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Valemetostat is a dual inhibitor of enhancer of zeste homolog 1 (EZH1) and EZH2.1 It inhibits polycomb repressive complex 2 (PRC2) containing EZH1 or EZH2 as the catalytic subunit in cell-free assays (IC50s = 8.4 and 2.5 nM, respectively).
产品描述

Valemetostat is a dual inhibitor of enhancer of zeste homolog 1 (EZH1) and EZH2.1 It inhibits polycomb repressive complex 2 (PRC2) containing EZH1 or EZH2 as the catalytic subunit in cell-free assays (IC50s = 8.4 and 2.5 nM, respectively). Valemetostat inhibits trimethylation of histone H3 lysine 27 in HCT116 cells (IC50 = 0.44 nM). It inhibits the growth of Karpas-422 diffuse large B cell lymphoma (DLBCL) cells (GI50 = 4.8 nM).
同义词

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通路

Others
靶点

Other Targets
受体

EZH1/2
研究领域

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适应症

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计算器

产品手册

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