
L-168049
CAS No. 191034-25-0
L-168049 ( L-168,049 )
产品货号. M27645 CAS No. 191034-25-0
人胰高血糖素受体(hGR)拮抗剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥915 | 有现货 |
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10MG | ¥1531 | 有现货 |
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25MG | ¥3216 | 有现货 |
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50MG | ¥4771 | 有现货 |
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100MG | ¥6828 | 有现货 |
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500MG | ¥14013 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称L-168049
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述人胰高血糖素受体(hGR)拮抗剂。
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产品描述human glucagon receptor (hGR) antagonist(In Vitro):In Chinese hamster ovary cells expressing the human glucagon receptor, L-168049 increases the apparent EC50 of glucagon-stimulated adenylate cyclase and decreases maximal glucagon stimulation with a Kb of 25 nM. L-168049 blocks glucagon-stimulated cAMP formation in mouse liver membrane and inhibits glucagon (100 pM)-stimulated cAMP synthesis in CHO cells expressing the human glucagon receptor with IC50 of 41 nM .(In Vivo):In the liver of L-G6pc-/- mice, L-168049 (50 mg/kg body; p.o.) reduces Pck1 mRNA expression by half within 6 hours. L-168049 prevents the increase in G6pc expression in the kidney and gut .
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体外实验L-168049 (compound 49) inhibits glucagon (100 pM) stimulated cAMP synthesis in CHO cells expressing the human glucagon receptor (hGIAR) (IC50 of 41 nM). L-168049 blocks cAMP formation stimulated by glucagon in murine liver membranes. L-168049 increases the apparent EC50 for glucagon stimulation of adenylyl cyclase in Chinese hamster ovary cells expressing the human glucagon receptor and decreases the maximal glucagon stimulation observed, with a Kb of 25 nM.
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体内实验In the liver of L-G6pc?/- mice, Pck1 mRNA expression is decreased by half 6 h after the administration of L-168049 (50 mg/kg body; p.o.), demonstrating the efficiency of the suppression of glucagon signaling. In agreement with the role of glucagon in the induction of extrahepatic gluconeogenesis, the administration of the L-168049 prevents the increase of the G6pc expression in both the kidneys and intestine of 6 h-fasted L-G6pc?/- mice.
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同义词L-168,049
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number191034-25-0
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分子量467.79
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分子式C24H20BrClN2O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : ≥ 50 mg/mL (106.89 mM)
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SMILESCCCOc1ccc(Br)cc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.García González M, et al. [Droxicam-induced hepatitis. Description of 3 new cases and review of the literature]. Rev Clin Esp. 1994 Mar;194(3):170-2. Review. Spanish.
产品手册




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