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VX-222
CAS No. 1026785-59-0
VX-222 ( VCH-222;Lomibuvir )
产品货号. M10130 CAS No. 1026785-59-0
A potent and selective, nonnucleoside inhibitor of HCV NS5B polymerase inhibitor with Kd of 17 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥609 | 有现货 |
|
| 5MG | ￥1103 | 有现货 |
|
| 10MG | ￥1852 | 有现货 |
|
| 25MG | ￥3837 | 有现货 |
|
| 50MG | ￥5557 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称VX-222
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent and selective, nonnucleoside inhibitor of HCV NS5B polymerase inhibitor with Kd of 17 nM.
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产品描述A potent and selective, nonnucleoside inhibitor of HCV NS5B polymerase inhibitor with Kd of 17 nM; inhibits the 1b/Con1 HCV subgenomic replicon with EC50 of 17 nM, the M423I and A486S variants remaine susceptible to VX-222; exhibits non-competitive and selective inhibition in HCV NS5B of genotype 1a and 1b, with IC50 of 0.94 and 1.2 uM, respectively; displays fine pharmacokinetic prole in rats and dogs.HCV Infection Phase 2 Discontinued
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同义词VCH-222;Lomibuvir
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通路Microbiology/Virology
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靶点HCV
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受体HCVNS5B1a;HCVNS5B1b
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研究领域Infection
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适应症HCV Infection
化学信息
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CAS Number1026785-59-0
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分子量445.61
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分子式C25H35NO4S
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 32 mg/mL
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SMILESCC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O
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化学全称2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Yi G, et al. Antimicrob Agents Chemother. 2012 Feb;56(2):830-7.
2. Jiang M, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5456-65.
3. Di Bisceglie AM, et al. Eur J Gastroenterol Hepatol. 2014 Jul;26(7):761-73.
2. Jiang M, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5456-65.
3. Di Bisceglie AM, et al. Eur J Gastroenterol Hepatol. 2014 Jul;26(7):761-73.
产品手册
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