021-51111890
购物车（0）
sales@molnova.cn
VU6005649
CAS No. 2137047-43-7
VU6005649 ( —— )
产品货号. M26504 CAS No. 2137047-43-7
VU6005649 是 CNS 渗透性 mGlu7/8 受体的激动剂（EC50：对于 mGlu7 受体和 mGlu8 受体分别为 0.65 μM 和 2.6 μM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥356 | 有现货 |
|
| 5MG | ￥583 | 有现货 |
|
| 10MG | ￥988 | 有现货 |
|
| 25MG | ￥2130 | 有现货 |
|
| 50MG | ￥4172 | 有现货 |
|
| 100MG | ￥6294 | 有现货 |
|
| 500MG | ￥12879 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称VU6005649
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述VU6005649 是 CNS 渗透性 mGlu7/8 受体的激动剂（EC50：对于 mGlu7 受体和 mGlu8 受体分别为 0.65 μM 和 2.6 μM）。
-
产品描述VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).(In Vitro):VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively). VU6005649 displays a terminal Kp of 2.43 with total brain levels ~9× above the mGlu7 positive allosteric modulator (PAM) in vitro EC50.(In Vivo):In wild-type mice, VU6005649 shows modest but significant pro-cognitive effects on associative learning and the first example of the efficacy of a mGlu7/8 positive allosteric modulator (PAM) in this model.
-
体外实验VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively. VU6005649 displays a terminal Kp of 2.43 with total brain levels ~9× above the mGlu7 positive allosteric modulator (PAM) in vitro EC50.
-
体内实验When VU6005649 (compound 9f) is dosed at 30 mg/kg IP in 10% Tween 80/H2O (0.75 mg/kg. s.c. amphetamine), no efficacy is observed in this assay. VU6005649 shows modest but significant pro-cognitive effects on associative learning in wild-type mice and the first example of efficacy of an mGlu7/8 positive allosteric modulator (PAM) in this model.
-
同义词——
-
通路Neuroscience
-
靶点GluR
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number2137047-43-7
-
分子量357.284
-
分子式C16H12F5N3O
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 50 mg/mL (139.95 mM)
-
SMILESCOc1ccc(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1F
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Chen XL, et al. An uncommon plant growth regulator, diethyl aminoethyl hexanoate, is highly effective in tissue cultures of the important medicinal plant purple coneflower (Echinacea purpurea L.). Biomed Res Int. 2013;2013:540316.
