USP8-IN-22d

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的选择性泛素特异性蛋白酶 USP8 抑制剂，IC50 为 0.85 uM。

A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.85 uM; shows no inhibitory activity for USP7 (IC50>100 uM).

DUBs-IN-1 (22 d) is an active inhibitor of ubiquitin-specific proteases, with an IC50 of 0.85 μM for USP8. DUBs-IN-1 is inactive toward USP7 (IC50, >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50s ranging from 0.5 μM to 1.5?μM.

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Proteasome/Ubiquitin

DUB

DUB

Cancer

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924296-18-4

337.3342

C20H11N5O

>98% (HPLC)

DMSO: 20 mg/mL

C1=CC=C(C=C1)CON=C2C3=CC=CC=C3C4=NC(=C(N=C42)C#N)C#N

9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(phenylmethoxy)imino]-

(-20℃)

With Ice Pack

≥ 2 years