ULK-101 ( ULK101 )

产品货号. M16932 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量

拼团产品询价大包装询价加入购物车

产品名称

ULK-101
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ULK-101 (ULK101) is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM, inhibits ULK2 with IC50 of 30 nM.
产品描述

ULK-101 (ULK101) is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM, inhibits ULK2 with IC50 of 30 nM; reduces Ser15 phosphorylation in a concentration-dependent manner in cell-based assay (EC50=390 nM), which is more potent than SBI-0206965 showing a cellular EC50 of 2.4 uM; displays desirable kinome selectivity profile; suppresses autophagy induction and autophagic flux in response to different stimuli, ULK1 inhibition sensitizes KRAS mutant lung cancer cells to nutrient stress.
同义词

ULK101
通路

Autophagy
靶点

ULK
受体

ULK
研究领域

——
适应症

——

CAS Number

--
分子量

460.45
分子式

C22H16F4N4OS
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(C1=CC(C2=C3N=CC(C4=CC=C(F)C=C4)=CN3N=C2)=CS1)N[C@@H](C5CC5)C(F)(F)F
化学全称

(S)-N-(1-cyclopropyl-2,2,2-trifluoroethyl)-4-(6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide

1. Martin KR, et al. iScience. 2018 Oct 26;8:74-84. doi: 10.1016/j.isci.2018.09.012.

计算器

产品手册

关联产品

SR-19871

A novel potent ULK1 inhibitor with IC50 of 11 nM.
LYN-1604

LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 uM against MDA-MB-231 cells).
SBI-0206965

SBI-0206965 (SBI 0206965) is a potent and specific small molecule ULK1 kinase inhibitor with IC50 of 108 nM.