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PD146176
CAS No. 4079-26-9
PD146176 ( NSC168807 )
产品货号. M24370 CAS No. 4079-26-9
PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.?PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥332 | 有现货 |
|
| 10MG | ￥599 | 有现货 |
|
| 25MG | ￥1199 | 有现货 |
|
| 50MG | ￥2228 | 有现货 |
|
| 100MG | ￥3904 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PD146176
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.?PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
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产品描述PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.?PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
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同义词NSC168807
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通路Autophagy
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靶点Autophagy
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受体15-LO;Autophagy
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研究领域——
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适应症——
化学信息
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CAS Number4079-26-9
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分子量237.3
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分子式C15H11NS
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纯度>98% (HPLC)
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溶解度DMSO:25 mg/mL (105.34 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
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SMILESC1C2=C(C3=CC=CC=C3S1)NC4=CC=CC=C24
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Bocan TM, et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit [published correction appears in Atherosclerosis 1998 Jul;139(1):201]. Atherosclerosis. 1998;136(2):203-216.
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