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SMER-28
CAS No. 307538-42-7
SMER-28 ( SMER28 )
产品货号. M13983 CAS No. 307538-42-7
A small-molecule enhancer/inducer of Autophagy; decreases the levels of Aβ peptide (EC50=10 uM) and APP-CTF (EC50 of 20 uM) in a γ-secretase-independent manner in primary neuronal cultures, Atg5, Beclin1 and Ulk1 are shown to be involved in the degradation of Aβ and APP-CTF.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥381 | 有现货 |
|
| 10MG | ￥543 | 有现货 |
|
| 25MG | ￥1045 | 有现货 |
|
| 50MG | ￥2001 | 有现货 |
|
| 100MG | ￥3848 | 有现货 |
|
| 200MG | ￥5630 | 有现货 |
|
| 500MG | ￥8829 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SMER-28
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A small-molecule enhancer/inducer of Autophagy; decreases the levels of Aβ peptide (EC50=10 uM) and APP-CTF (EC50 of 20 uM) in a γ-secretase-independent manner in primary neuronal cultures, Atg5, Beclin1 and Ulk1 are shown to be involved in the degradation of Aβ and APP-CTF.
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产品描述A small-molecule enhancer/inducer of Autophagy; decreases the levels of Aβ peptide (EC50=10 uM) and APP-CTF (EC50 of 20 uM) in a γ-secretase-independent manner in primary neuronal cultures, Atg5, Beclin1 and Ulk1 are shown to be involved in the degradation of Aβ and APP-CTF; enhances erythropoiesis in a range of in vitro and in vivo models of DBA, and protects against neurodegeneration in Drosophila model of Huntington’s disease.
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同义词SMER28
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通路Autophagy
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靶点Autophagy
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受体Autophagy
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number307538-42-7
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分子量264.12
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分子式C11H10BrN3
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 32 mg/mL
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SMILESC=CCNC1=C2C=C(Br)C=CC2=NC=N1
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化学全称4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Doulatov S, et al. Sci Transl Med. 2017 Feb 8;9(376). pii: eaah5645.
2. Rosenthal AK, et al. J Biol Chem. 2015 May 22;290(21):13028-38.
3. Sarkar S, et al. Nat Chem Biol. 2007 Jun;3(6):331-8.
4. Tian Y et al. FASEB J. 2011 Jun;25(6):1934-42.
2. Rosenthal AK, et al. J Biol Chem. 2015 May 22;290(21):13028-38.
3. Sarkar S, et al. Nat Chem Biol. 2007 Jun;3(6):331-8.
4. Tian Y et al. FASEB J. 2011 Jun;25(6):1934-42.
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