Tryptanthrin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

色胺酮是一种天然的 DNA 旋转酶抑制剂。

Tryptanthrin is a natural DNA gyrase inhibitor.

Cell Viability Assay Cell Line:MCF-7 cells Concentration:0-60 μM Incubation Time:24, 48 and 72 hours Result:Increased the inhibition rates of MCF-7 cells in a dose- and time- dependent manner.Western Blot Analysis Cell Line:MCF-7 cells Concentration:6.25, 12.5, and 25 μM Incubation Time:48 hours Result:Increased the E-cadherin protein levels and markedly upregulated the protein expression levels of MMP-2 and Snail in MCF-7 cells induced by TGF-β1.

Animal Model:Female Bal b/c mice with 4T1 xenograft Dosage:25, 50, and 100 mg/kg Administration:Oral gavage; daily, for 13 days Result:Inhibited tumor growth in a dose-dependent manner.Animal Model:Male Wistar Han rats (220–230 g) Dosage:10 mg/kg Administration:Oral administration; once Result:Reduced LTB4 pleural levels by 46%.Reduced PGE2 levels (by 42%), exudate volume (by 80%) and the number of infiltrating cells (by 41%).

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Cell Cycle/DNA Damage

DNA gyrase

DNA gyrase

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13220-57-0

248.24

C15H8N2O2

>98% (HPLC)

DMSO:8 mg/mL (32.22 mM)

O=C1c2ccccc2-n2c1nc1ccccc1c2=O

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(-20℃)

With Ice Pack

≥ 2 years