Tropisetron

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.

Tropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.(In Vitro):The IC50 value of Tropisetron for the 5-HT3 receptor is 70.1 ± 0.9 nM. Tropisetron inhibits IL-2 production and antigen-induced proliferation in human peripheral T cells and inhibits signaling pathways that regulate the activation of transcription factors AP-1, NFAT, and NF-κB.(In Vivo):Tolbisetron induces anti-inflammatory effects in experimental models of cisplatin-induced nephrotoxicity that are completely independent of the 5-HT3 receptor. Tropisetron can improve ischemic brain injury by reducing TNF-α levels and myeloperoxidase activity.

ICS 205-930; Tropisetronum; Tropisteron

Endocrinology/Hormones

5-HT Receptor

TRPM8

——

——

89565-68-4

284.4

C17H20N2O2

>98% (HPLC)

——

CN1C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12

——

(-20℃)

With Ice Pack

≥ 2 years