Tolrestat

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tolrestat 是一种有效的醛糖还原酶抑制剂 (IC50 = 35 nM)。

Tolrestat is a potent inhibitor of aldose reductase (IC50 = 35 nM).(In Vivo):The estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil, respectively in diabetic rats. Tolrestat inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice. Tolrestat (1.8 mg/kg) causes a reversal of normal RBC sorbitol levels.

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Tolrestat (1.8 mg/kg per day) causes a reversal to normal RBC sorbitol levels diabetic rats. In 21-day diabetic rats, the estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil,respectively. Either tolrestat or sorbinil inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice.

AY-27773

Endocrinology/Hormones

Reductase

SIRT7

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82964-04-3

357.35

C16H14F3NO3S

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (139.92 mM)

COc1ccc2c(cccc2c1C(F)(F)F)C(=S)N(C)CC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years