Tianeptinaline ( —— )

产品货号. M17052 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Tianeptinaline
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Tianeptinaline is a class I HDAC-selective, brain penetrant analogue of tianeptine with IC50 of 0.24, 0.12 and 0.155 uM for HDAC1, 2 and 3 respectively.
产品描述

Tianeptinaline is a class I HDAC-selective, brain penetrant analogue of tianeptine with IC50 of 0.24, 0.12 and 0.155 uM for HDAC1, 2 and 3 respectively, does not inhibit HDAC6; has EC50 of 3.98 and 0.67 uM in H3K9ac and H4K12ac assays, respectively; increases histone acetylation, and enhances CREB-mediated transcription and the expression of Arc (activity-regulated cytoskeleton-associated protein); enhances contextual fear conditioning, a behavioral test of hippocampal-dependent memory, after in vivo administration.
同义词

——
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC
研究领域

——
适应症

——

CAS Number

——
分子量

527.08
分子式

C27H31ClN4O3S
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(NC1=CC=CC=C1N)CCCCCNC(C2=CC=C(Cl)C=C23)C4=CC=CC=C4N(C)S3(=O)=O
化学全称

N-(2-aminophenyl)-7-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanamide

1. Zhao WN, et al. ACS Chem Neurosci. 2018 Jun 22. doi: 10.1021/acschemneuro.8b00116.

计算器

产品手册

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