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Thioguanine

CAS No. 154-42-7

Thioguanine ( —— )

产品货号. M18075 CAS No. 154-42-7

硫鸟嘌呤是一种抗肿瘤化合物,还具有抗代谢作用。该药用于治疗急性白血病。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
50MG ¥324 有现货
100MG ¥389 有现货
500MG ¥583 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Thioguanine
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    硫鸟嘌呤是一种抗肿瘤化合物,还具有抗代谢作用。该药用于治疗急性白血病。
  • 产品描述
    Tioguanine (INN, BAN), or thioguanine (AAN, USAN), commonly referred to as 6-thioguanine (6-TG) is a medication used to treat a number of types of leukemia. It has been used less frequently in recent years because of safety concerns. However, it is becoming more widely used for treating ulcerative colitis and some autoimmune diseases.(In Vitro):6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively. 6-Thioguanine (Thioguanine) affects the methylation of cytosine residues by purified DNA methyltransferases including human DNMT1 and bacterial HpaII methylase. 6-Thioguanine (Thioguanine) (1 or 3 μM) decreases global cytosine methylation in Jurkat T cells and cytosine methylation in human cells at 3 μM. 6-Thioguanine (Thioguanine) (18.75, 37.50, or 75.00 μM) adversely affects cell viability, but with no effect on LDH or ALT activity.
  • 体外实验
    6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively. 6-Thioguanine (Thioguanine) affects the methylation of cytosine residues by purified DNA methyltransferases including human DNMT1 and bacterial HpaII methylase. 6-Thioguanine (Thioguanine) (1 or 3 μM) decreases global cytosine methylation in Jurkat T cells and cytosine methylation in human cells at 3 μM. 6-Thioguanine (Thioguanine) (18.75, 37.50, or 75.00 μM) adversely affects cell viability, but with no effect on LDH or ALT activity.
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    DNMT1
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    154-42-7
  • 分子量
    167.2
  • 分子式
    C5H5N5S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : 10 mg/mL 59.81 mM
  • SMILES
    c1nc2c([nH]1)c(=S)nc([nH]2)N
  • 化学全称
    2-amino-1H-purine-6(7H)-thione

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Krynetskaia NF, et al. FASEB J,2000, 14(14), 2339-2344.
产品手册
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