EN6 ( —— )

产品货号. M23822 CAS No. 1808714-73-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

EN6
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling.
产品描述

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy.?EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner.?EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).?
同义词

——
通路

Others
靶点

Other Targets
受体

Others
研究领域

——
适应症

——

CAS Number

1808714-73-9
分子量

368.3
分子式

C19H14F2N4O2
纯度

>98% (HPLC)
溶解度

DMSO: 4.63 mg/mL (12.57 mM; Need ultrasonic); Ethanol: 1.10 mg/mL (2.99 mM; ultrasonic and warming and heat to 60°C)
SMILES

C=CC(Nc(cc(cc1)NC(c2cn(-c(cccc3)c3F)nc2)=O)c1F)=O
化学全称

——

1.Chung CY, et al. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol. 2019 Aug;15(8):776-785.

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