• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

Telithromycin

CAS No. 191114-48-4

Telithromycin ( Telithromycin | HMR-3647 | HMR 3647 )

产品货号. M18169 CAS No. 191114-48-4

泰利霉素是一种酮内酯抗生素,用于治疗轻度至中度的社区获得性肺炎。抗菌泰利霉素通过干扰细菌的蛋白质合成来防止细菌生长。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥794 有现货
10MG ¥1442 有现货
25MG ¥3281 有现货
50MG ¥5281 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Telithromycin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    泰利霉素是一种酮内酯抗生素,用于治疗轻度至中度的社区获得性肺炎。抗菌泰利霉素通过干扰细菌的蛋白质合成来防止细菌生长。
  • 产品描述
    Telithromycin is a ketolide antibiotic to treat community acquired pneumonia of mild to moderate severity. Antibacterial Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and blocks the progression of the growing polypeptide chain. Telithromycin has over 10 times higher affinity to the subunit 50S than erythromycin. In addition, telithromycin strongly bind simultaneously to two domains of 23S RNA of the 50 S ribosomal subunit, where older macrolides bind strongly only to one domain and weakly to the second domain. Telithromycin can also inhibit the formation of ribosomal subunits 50S and 30S.(In Vitro):Telithromycin (HMR3647) (0-50 μg/mL, 30 min) suppress C. pneumoniae-induced MUC5AC production.Telithromycin (0-50 μg/mL, 30 min) suppress C. pneumoniae-induced NF-kB activation.Telithromycin (10 mg/mL, 1 h) inhibits the production of MIP-2 and TNF-α in a dose-dependent manner by LPS-stimulated RAW 264.7 macrophages.Telithromycin (10 mg/mL, 1 h) inhibits NF-kB activation, increases apoptosis in cell and decreases the LPS-induced influx of neutrophils in BAL fluid.(In Vivo):Telithromycin (HMR3647) (20 mg/kg, ip., single) reduces protein, nitrite, MIP-2, and TNF-α levels in the BAL fluid of LPS-nebulized animals.
  • 体外实验
    Telithromycin (HMR3647) (0-50 μg/mL, 30 min) suppress C. pneumoniae-induced MUC5AC production.Telithromycin (0-50 μg/mL, 30 min) suppress C. pneumoniae-induced NF-kB activation.Telithromycin (10 mg/mL, 1 h) inhibits the production of MIP-2 and TNF-α in a dose-dependent manner by LPS-stimulated RAW 264.7 macrophages.Telithromycin (10 mg/mL, 1 h) inhibits NF-kB activation, increases apoptosis in cell and decreases the LPS-induced influx of neutrophils in BAL fluid:RT-PCR Cell Line:NCI-H292 cells Concentration: 0-50 μg/mL Incubation Time:30 min Result:Suppressed C. pneumoniae-induced MUC5AC production in dose-dependently and significantly decreased MUC5AC production at 50 mg/mL.Suppressed p65 and p50 activation in NCI-H292 cells.Apoptosis Analysis Cell Line:RAW 264.7 and MLE-12 cells Concentration:10 mg/mL Incubation Time:1 h Result:Increased the apoptotic activity in cells induced with supernatants from LPS-treated RAW 264.7 macrophages and in LPS-induced cells.
  • 体内实验
    Telithromycin (HMR3647) (20 mg/kg, ip., single) reduces protein, nitrite, MIP-2, and TNF-α levels in the BAL fluid of LPS-nebulized animals. Animal Model:LPS-Nebulized MiceDosage:20 mg/kg Administration:20 mg/kg, ip., single Result:Increased the protein concentration, reduced the concentrations of nitrite and the levels of TNF-α and induced significant reductions the levels of MIP-2.
  • 同义词
    Telithromycin | HMR-3647 | HMR 3647
  • 通路
    Endocrinology/Hormones
  • 靶点
    5-HT Receptor
  • 受体
    Antibacterial
  • 研究领域
    Infection
  • 适应症
    ——

化学信息

  • CAS Number
    191114-48-4
  • 分子量
    812
  • 分子式
    C43H65N5O10
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 100 mg/mL; 123.15 mM
  • SMILES
    CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(c3)-c3cccnc3)C(=O)O[C@]12C)OC
  • 化学全称
    (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)butyl)octahydro-2H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetraone

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

产品手册
关联产品
  • Doxepin hydrochlorid...

    Doxepin hydrochloride 是一种具有口服活性的三环抗抑郁剂。Doxepin hydrochloride 是一种有效的选择性组胺受体 H1 拮抗剂。Doxepin hydrochloride 也是一种有效的 CYP450 抑制剂,并显着抑制 CYP450 2C19 和 CYP450 1A2。

  • Cyproheptadine hydro...

    Cyproheptadine salticide sesqui所述是一种抗组胺药,也是血清素和组胺2的拮抗剂。

  • Tamoxifen

    他莫昔芬是乳腺组织中雌激素受体的拮抗剂。