Talampanel ( GYKI-53773 | LY-300164 )

产品货号. M26835 CAS No. 161832-65-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Talampanel
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Talampanel 是一种口服选择性 α-氨基-3-羟基-5-甲基-4-异恶唑丙酸酯受体拮抗剂，具有抗癫痫活性。
产品描述

Talampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models.(In Vivo):Talampanel (p.o.; 5 mg/kg; once a day; 2 weeks) decreases motoneuronal calcium in a mouse model of ALS .
体外实验

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体内实验

Talampanel (orally administration; 5 mg/kg; once a day; 2 weeks) reduces motoneuronal calcium in a mouse model of ALS, but its efficacy declines as the disease progresses. Animal Model:Female mutant SOD1 Tg mice Dosage:5 mg/kg Administration:Orally administration; 5 mg/kg; once a day; 2 weeks Result:Had a significant effect in reducing the calcium level only at the age of 12 weeks.
同义词

GYKI-53773 | LY-300164
通路

Apoptosis
靶点

Apoptosis
受体

ASK1
研究领域

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适应症

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1.Kawarazaki Y, Ichijo H, Naguro I. Apoptosis signal-regulating kinase 1 as a therapeutic target. Expert Opin Ther Targets. 2014 Jun;18(6):651-64.

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