TP0903

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TP-0903 是一种有效的选择性 Axl 激酶抑制剂，IC50 为 27 nM。

TP-0903 is a potent and selective Axl kinase inhibitor with IC50 of 27 nM.

Dubermatinib (TP-0903) displays a potent activity against AXL with an IC50 of 0.027 μM. Dubermatinib (TP-0903) shows extremely potent activity in cell viability assays with an IC50 of 6 nM against the pancreatic cancer cell line PSN-1. Dubermatinib (TP-0903) is evaluated for its ability to block GAS6-mediated activation of AXL in pancreatic cancer cells. PSN-1 cells are serum-starved and then stimulated with GAS6 in the presence of various concentrations of TP-0903.

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TP-0903 | TP 0903 | TP0903 | Dubermatinib

Tyrosine Kinase

TAM Receptor

AXL

Cancer

Solid Tumors

1341200-45-0

516.06

C24H30ClN7O2S

>98% (HPLC)

Ethanol: 6 mg/mL warmed (11.62 mM); DMSO: 7 mg/mL warmed (13.56 mM)

O=S(C1=CC=CC=C1NC2=NC(NC3=CC=C(CN4CCN(C)CC4)C=C3)=NC=C2Cl)(N(C)C)=O

2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide

(-20℃)

With Ice Pack

≥ 2 years