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THPP-1
CAS No. 1257051-63-0
THPP-1 ( —— )
产品货号. M22050 CAS No. 1257051-63-0
THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥356 | 有现货 |
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| 5MG | ￥583 | 有现货 |
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| 10MG | ￥988 | 有现货 |
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| 25MG | ￥2130 | 有现货 |
|
| 50MG | ￥3621 | 有现货 |
|
| 100MG | ￥5338 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称THPP-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).
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产品描述THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively). Consistent with rodent data, both THPP-1 and risperidone significantly attenuated the stimulant effects in SIMA when administered alone, though some differences were noted.?Combination therapy with a low dose of risperidone produced significantly more robust effects.?THPP-1 and risperidone also produced a marked reduction of wake cycle time and gamma frequency power in EEG.?However, THPP-1 differed from risperidone by reducing spectral power of lower frequencies.
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同义词——
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通路Angiogenesis
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靶点PDE
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受体PDE10A
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研究领域——
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适应症——
化学信息
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CAS Number1257051-63-0
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分子量464.9
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分子式C23H21ClN6O3
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纯度>98% (HPLC)
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溶解度DMSO:31 mg/mL (66.68 mM; Need ultrasonic)
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SMILESCOCCOC1=C2CN(CCC2=NC(=N1)C1=CC=C(Cl)N=C1)C(=O)C1=C2C=CC=CN2C=N1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Vardigan JD, et al. Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel rhesus model of antipsychotic activity. Psychopharmacology (Berl). 2016 Jul;233(13):2441-50.
产品手册
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