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TH1020
CAS No. 1841460-82-9
TH1020 ( —— )
产品货号. M22635 CAS No. 1841460-82-9
TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12?μm) and specificity.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥316 | 有现货 |
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| 5MG | ￥518 | 有现货 |
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| 10MG | ￥786 | 有现货 |
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| 25MG | ￥1604 | 有现货 |
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| 50MG | ￥3013 | 有现货 |
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| 100MG | ￥4504 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TH1020
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12?μm) and specificity.
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产品描述TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12?μm) and specificity.TH1020 was repress the expression of downstream TNF-α signaling pathways mediated by the TLR5/flagellin complex formation.?Based on molecular docking simulation, TH1020 is suggested to compete with flagellin and disrupt its association with TLR5.?TH1020 provides a much-needed molecular probe for studying this important protein-protein interaction and a lead compound for identifying novel therapeutics targeting TLR5.
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同义词——
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通路GPCR/G Protein
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靶点Antibacterial
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受体TLR5;Bacterial
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研究领域——
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适应症——
化学信息
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CAS Number1841460-82-9
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分子量453.54
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分子式C23H15N7S2
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纯度>98% (HPLC)
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溶解度DMSO:2 mg/mL (4.41 mM; ultrasonic and warming and adjust pH to 2 with 1M HCl and heat to 80°C)
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SMILESC(c1ccccc1)n1c(Sc2ncnc3c4cccnc4sc23)nnc1-c1ccncc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Lei Yan, et al. Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors. ChemMedChem. 2016 Apr 19;11(8):822-6.
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