TD-139

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TD-139 (TD139) 是一种高效、选择性的 Galectin-3 (Gal-3) 碳水化合物结合域抑制剂，Ki 为 14 nM。

TD-139 (TD139) is a highly potent, selecitve inhibitor of Galectin-3 (Gal-3) carbohydrate binding domain with Ki of 14 nM; reduces TGF-β1-induced β-catenin translocation to the nucleus, blocks β-catenin phosphorylation in vitro and in vivo; attenuates the late-stage progression of lung fibrosis in murine models; attenuates liver injury and milder infiltration of IFNγ- and IL-17- and -4-producing CD4(+) T cells, increases IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activated macrophages and prevents the apoptosis of liver-infiltrating MNCs in WT C57BL/6 mice.Cystic Fibrosis,Phase 2 Clinical

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TD139 | TD 139

Cytoskeleton/Cell Adhesion Molecules

Galectin

galectin-3

Other Indications

Fibrosis

1450824-22-2

648.635

C28H30F2N6O8S

>98% (HPLC)

DMSO: 1 mg/mL (Need ultrasonic); H2O: < 5 mg/mL; Ethanol: 0.1 mg/mL (Need ultrasonic and warming)

O[C@H]([C@@H](N1N=NC(C2=CC=CC(F)=C2)=C1)[C@H]([C@@H](CO)O3)O)[C@@H]3S[C@H]4[C@@H]([C@@H](N5N=NC(C6=CC=CC(F)=C6)=C5)[C@H]([C@@H](CO)O4)O)O

β-D-Galactopyranoside, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-β-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-

(-20℃)

With Ice Pack

≥ 2 years