
TAS-119
CAS No. 1453099-83-6
TAS-119 ( —— )
产品货号. M34717 CAS No. 1453099-83-6
TAS-119 是一种有效的,选择性的,具有口服活性的 Aurora A 抑制剂,IC50 为 1.0 nM。TAS-119 对 Aurora A 的选择性高于其他蛋白激酶,包括 Aurora B (IC50 为 95 nM)。TAS-119 具有有效的抗肿瘤活性。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥1266 | 有现货 |
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5MG | ¥1995 | 有现货 |
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10MG | ¥3206 | 有现货 |
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25MG | ¥6162 | 有现货 |
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50MG | ¥9619 | 有现货 |
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100MG | ¥13235 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称TAS-119
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述TAS-119 是一种有效的,选择性的,具有口服活性的 Aurora A 抑制剂,IC50 为 1.0 nM。TAS-119 对 Aurora A 的选择性高于其他蛋白激酶,包括 Aurora B (IC50 为 95 nM)。TAS-119 具有有效的抗肿瘤活性。
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产品描述TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites.
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体外实验TAS-119 enhances the antiproliferative effect of Paclitaxel in a variety of human cancer cell lines, including Paclitaxel-resistant cells.TAS-119 (30-300 nM) dose dependently enhances cell growth inhibition by three taxanes (Paclitaxel, Docetaxel, and Cabazitaxel) in HeLa cells. TAS-119 induces mitotic accumulation predominantly in tumor cells, compared with that in normal diploid fibroblasts.
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体内实验TAS-119 (5-30 mg/kg; oral administration; twice daily on day 1 and everyday on day 2) treatment induces phosphorylated histone H3 (pHH3) in nude rats with the HeLa-luc xenografts.Animal Model:Nude rats injected with HeLa-luc cells Dosage:5 mg/kg, 10 mg/kg, and 30 mg/kg Administration:Oral administration; twice daily on day 1 and everyday on day 2 Result:Induced pHH3 at all doses in nude rats with the HeLa-luc xenografts.
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同义词——
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通路Cell Cycle/DNA Damage
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靶点Aurora Kinase
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受体Aurora Kinase
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研究领域——
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适应症——
化学信息
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CAS Number1453099-83-6
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分子量506.36
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分子式C23H22Cl2FN5O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 50 mg/mL (98.74 mM; 超声助溶 )
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SMILESCc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3Cl)C(O)=O)ccc2F)n[nH]1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Hiroshi Sootome, et al. Aurora A Inhibitor TAS-119 Enhances Antitumor Efficacy of Taxanes In Vitro and In Vivo: Preclinical Studies as Guidance for Clinical Development and Trial Design. Mol Cancer Ther. 2020 Oct;19(10):1981-1991.?
产品手册




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