TAK-915 ( TAK915;TAK 915 )

产品货号. M12037 CAS No. 1476727-50-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

TAK-915
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM.
产品描述

TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM; dispalys 4100-fold selectivity over PDE1A, and >20,000-fold over other PDE isoforms; robustly increased cGMP levels in the rat brain, attenuates MK-801-induced episodic memory deficits in rats. Schizophrenia Phase 1 Clinical
同义词

TAK915;TAK 915
通路

Angiogenesis
靶点

PDE
受体

PDE
研究领域

Neurological Disease
适应症

Schizophrenia

CAS Number

1476727-50-0
分子量

458.37
分子式

C19H18F4N4O5
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(N1C2=NC=C(OC)C=C2NC(C1)=O)N[C@@H](C3=CC=C(OC(F)(F)F)C(F)=C3)COC
化学全称

N-((1S)-1-(3-fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide

1. Mikami S, et al. J Med Chem. 2017 Sep 28;60(18):7677-7702.

计算器

产品手册

关联产品

Aminophylline

Aminophylline is a competitive nonselective phosphodiesterase inhibitor that is used to treat airway obstruction from asthma or COPD.
GSK-256066

A potent, selective PDE4 inhibitor with pIC50 of 11.5, 11.3, 11.4, and 11.9 for PDE4B, A, C, and D, respectively.
Lotamilast

Lotamilast (RVT 501, E6005) is apotent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM.