TAK-259
CAS No. 1192348-73-4
TAK-259 ( TAK259;TAK 259 )
产品货号. M10667 CAS No. 1192348-73-4
A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TAK-259
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively.
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产品描述A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively; shows antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, ameliorates cystitis-induced urinary frequency in rats.Other Indication Phase 1 Discontinued
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同义词TAK259;TAK 259
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通路Angiogenesis
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靶点Adrenergic Receptor
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受体Adrenergic Receptor
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研究领域Other Indications
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适应症Other Disease
化学信息
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CAS Number1192348-73-4
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分子量374.24
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分子式C14H13Cl2N3O3S
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纯度>98% (HPLC)
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溶解度——
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SMILESCS(=O)(=O)C1=C(C=C(C=C1)Cl)CN2C=C(C=C(C2=N)C(=O)N)Cl
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化学全称5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sakauchi N, et al. J Med Chem. 2016 Apr 14;59(7):2989-3002.
产品手册
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