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TAK-259

CAS No. 1192348-73-4

TAK-259 ( TAK259;TAK 259 )

产品货号. M10667 CAS No. 1192348-73-4

A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    TAK-259
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively.
  • 产品描述
    A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively; shows antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, ameliorates cystitis-induced urinary frequency in rats.Other Indication Phase 1 Discontinued
  • 同义词
    TAK259;TAK 259
  • 通路
    Angiogenesis
  • 靶点
    Adrenergic Receptor
  • 受体
    Adrenergic Receptor
  • 研究领域
    Other Indications
  • 适应症
    Other Disease

化学信息

  • CAS Number
    1192348-73-4
  • 分子量
    374.24
  • 分子式
    C14H13Cl2N3O3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    CS(=O)(=O)C1=C(C=C(C=C1)Cl)CN2C=C(C=C(C2=N)C(=O)N)Cl
  • 化学全称
    5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Sakauchi N, et al. J Med Chem. 2016 Apr 14;59(7):2989-3002.
产品手册
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