Suramin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种抗锥虫化合物，还具有抗肿瘤活性；通过破坏其募集 Cdc34 的能力来抑制 CRL（Cullin-RING E3 泛素连接酶）活性。

An antitrypansomal drug that also possesses antitumor activity; inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34; induces accumulation of CRL substrates; also inhibits multiple viruses (ZIKVs, EV71).Parasite Infection Approved.

Suramin (50-600 μg/mL; for 24-96 hours) inhibits cells proliferation in a dose-dependent and time-dependent manner and decreases viability in cancer cells. Suramin (300 μg/mL; for 48 hours) induces cells apoptosis, and down-regulates mRNA expression in HeLa cells. Suramin (1 mg/mL; 1 hour) significantly suppresses the phosphorylated ERK1/2. The IC50 values of HO-8910 PM and HeLa are 319 μg/mL, 476 μg/mL, respectively. Suramin blocks viral replication in Vero E6 cells. Cell Proliferation AssayCell Line:HO-8910 PM ovarian and Hela cervical cancer cells.Concentration:50, 100, 200, 300, 400, 500 and 600 μg/mL.Incubation Time:For 24, 48, 72 and 96 hours Result:Inhibited cells proliferation in a dose-dependent and time-dependent manner.Apoptosis Analysis Cell Line:HeLa cells.Concentration:300 μg/mL Incubation Time:For 48 hours Result:Induced cells apoptosis..Western Blot Analysis Cell Line:PA-SMCs cells Concentration:1 mg/mL Incubation Time:For 1 hours Result:Significantly suppressed the phosphorylated ERK1/2.

Suramin (10 mg/kg; IV; twice weekly for 3 weeks) reverses established pulmonary hypertension (PH), thereby normalizing the pulmonary artery pressure values and vessel structure. Animal Model:Adult male Wistar rats (200-225 g)Dosage:10 mg/kg Administration:IV; twice weekly for 3 weeks Result:Reversed established PH, thereby normalizing the pulmonary artery pressure values and vessel structure.

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GPCR/G Protein

P2Y Receptor

P2Y Receptor

Infection

Parasite Infection

145-63-1

1297.28

C51H40N6O23S6

>98% (HPLC)

10 mM in DMSO

CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C

1,3,5-Naphthalenetrisulfonic acid, 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-

(-20℃)

With Ice Pack

≥ 2 years