Solithromycin ( CEM-101 | OP-1068 )

产品货号. M15888 CAS No. 760981-83-7

一种新型氟酮内酯，其 MIC 低于泰利霉素和大环内酯类。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥259	有现货
5MG	￥413	有现货
10MG	￥721	有现货
25MG	￥1442	有现货
50MG	￥2373	有现货
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Solithromycin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种新型氟酮内酯，其 MIC 低于泰利霉素和大环内酯类。
产品描述

A novel fluoroketolide with lower MICs than those of telithromycin and macrolides; binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis; exhibits MICs of 7.5, 40, and 125 ng/ml for Streptococcus pneumoniae,Staphylococcus aureus, and Haemophilus influenzae, respectively. Bacterial Infection Approved(In Vitro):The IC50s values for Solithromycin on TNFα and CXCL8 release are 41.6 μM and 78.2 μM, respectively. Solithromycin markedly reduces MMP9 activity, with an IC50 of 14.9 μM.Solithromycin (0-333 μM; 72 hours; U937 and PBMC cells) suppresses lipopolysaccharide-induced TNFα release and phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase 9 (MMP9) activity, and does not affect cell viability in monocytic U937 and PBMC cells.(In Vivo):Solithromycin (100 mg/kg; oral administration; every day; for 8 days; C57BL/6J mice) treatment inhibits inflammatory cells accumulation and pro-MMP9 production in cigarette smoke-exposed mice.
体外实验

The IC50s values for Solithromycin on TNFα and CXCL8 release are 41.6 μM and 78.2 μM, respectively. Solithromycin markedly reduces MMP9 activity, with an IC50 of 14.9 μM.Solithromycin (0-333 μM; 72 hours; U937 and PBMC cells) suppresses lipopolysaccharide-induced TNFα release and phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase 9 (MMP9) activity, and does not affect cell viability in monocytic U937 and PBMC cells.
体内实验

Solithromycin (100 mg/kg; oral administration; every day; for 8 days; C57BL/6J mice) treatment inhibits inflammatory cells accumulation and pro-MMP9 production in cigarette smoke-exposed mice. Animal Model:C57BL/6J mice (male, 4 weeks)Dosage:100 mg/kg Administration:Oral administration; every day; for 8 days Result:Inhibited cigarette smoke-induced neutrophilia and pro-MMP9 production.
同义词

CEM-101 | OP-1068
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibiotic
研究领域

Infection
适应症

Bacterial Infection

化学信息

CAS Number

760981-83-7
分子量

845.0088
分子式

C43H65FN6O10
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 32 mg/mL
SMILES

CC[C@@H]1[C@@]2([C@@H]([C@@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@@](C(=O)O1)(C)F)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=N4)C5=CC(=CC=C5)N)C
化学全称

2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 1-[4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl]-4-ethyl-7-fluorooctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Waites KB, et al. Antimicrob Agents Chemother. 2009 May;53(5):2139-41. 2. Lemaire S, et al. Antimicrob Agents Chemother. 2009 Sep;53(9):3734-43. 3. Roblin PM, et al. Antimicrob Agents Chemother. 2010 Mar;54(3):1358-9.

计算器

浓度计算器

摩尔计算器

分子量计算器

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