STO-609

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

STO-609 是一种选择性且细胞渗透性的 CaM-KK 抑制剂。

STO-609 is a selective and cell-permeable inhibitor of CaM-KK; inhibits recombinant CaM-KKα and CaM-KKβ with Ki of 80 and 15 ng/ml; without any significant effect on the downstream CaM kinases (CaM-KI and -IV, IC50 >10 ug); suppresses the Ca(2+)-induced activation of CaM-KIV in a dose-dependent manner in transfected HeLa cells; significantly reduces the endogenous activity of CaM-KK in SH-SY5Y neuroblastoma cells (1 ug/ml, 80% inhibition).

STO-609 inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with Ki values of 80 and 15 ng/mL, respectively, and also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC50 value of the compound against CaM-KII is 10 μg/mL. STO-609 inhibits constitutively active CaM-KKα as well as the wild-type enzyme. In transfected HeLa cells, STO-609 suppresses the Ca2+-induced activation of CaM-KIV in a dose-dependent manner. STO-609 significantly reduces the endogenous activity of CaM-KK in SH-SY5Y neuroblastoma cells at a concentration of 1μg/mL (80% inhibitory rate).

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STO609 | ST O609

Endocrinology/Hormones

CaMK

CaM-KKα|CaM-KKβ|CaM-KK

Other Indications

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52029-86-4

314.2943

C19H10N2O3

>98% (HPLC)

DMSO: 5.6 mg/mL (Need ultrasonic and warming)

C1=CC=C2C(=C1)N=C3N2C(=O)C4=CC=CC5=C(C=CC3=C54)C(=O)O

7H-Benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, 7-oxo-

(-20℃)

With Ice Pack

≥ 2 years