Ginkgetin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

银杏素具有抗流感病毒和抗真菌活性。银杏素具有抗炎活性，可以下调体内 COX-2 的诱导，对抗皮肤炎症反应。

Ginkgetin has anti-influenza virus and anti-fungal activities. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. Ginkgetin is a good STAT3 inhibitor and may be a useful lead molecule for development of a therapeutic STAT3 inhibitor. Ginkgetin induces apoptosis in PC-3 cells via activation of caspase 3 and inhibition of survival genes as a potent chemotherapeutic agent for prostate cancer treatment. Ginkgetin has neuroprotective activity against neurological injury induced by MPTP occurs via regulating iron homeostasis, it may provide neuroprotective therapy for Parkinson's disease and iron metabolism disorder related diseases.

Ginkgetin (2.5-20 μM; 48 h) inhibits the growth of Daoy and D283 cell lines, and induces G2/M cell cycle arrest in Daoy cells.Ginkgetin (20-40 μM; 24 h) significantly activates the apoptosis of osteosarcoma cells in a concentration-dependent manner.Ginkgetin (10-20 μM; 3-24 h) down-regulated the expression of Wnt target genes without affecting the expression of β-catenin in medulloblastoma cells.Ginkgetin (1-10 μM; 24 or 48 h) significantly inhibits the VEGF-induced endothelial cell proliferation, migration, and wound recovery in a concentration-dependent manner.Ginkgetin (5-10 μM; 48 h) induces autophagy responsible for cell death in A549.Cell Viability Assay Cell Line:Daoy and D283 cell lines Concentration:2.5, 5, 10, 20 μM Incubation Time:48 hours Result:Inhibited the cell growth, with IC50s of 14.65 and 15.81 μM for Daoy and D283 cells, respectively.Apoptosis Analysis Cell Line:Osteosarcoma cells Concentration:20, 30, 40 μM Incubation Time:24 hours Result:Markedly induced the apoptosis of osteosarcoma cells in a concentration-dependent manner.Cell Cycle Analysis Cell Line:Daoy cells Concentration:2.5, 5, 10, 20 μM Incubation Time:24 hours Result:Increased G2/M phase, compared with that of control, indicating a G2/M cell phase arrest.Cell Cycle Analysis Cell Line:Daoy and D283 cell lines Concentration:10, 20 μM Incubation Time:3, 6, 12, 24 hours Result:Attenuated the expression of Wnt target genes, Axin2, cyclin D1 and survivin at 20 μM for 24 h in Daoy cells.Unaffected the level of total β-catenin and diminished the level of β-catenin phosphorylation in a time- and concentration-dependent manner.

Ginkgetin (25-100 mg/kg; i.p. 2 hours after the onset of ischemia) exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway.Ginkgetin (30 mg/kg; intragastrically once per day for 42 d) suppresses tumor growth in A549 cells bearing nude mice. Animal Model:Male Sprague-Dawley rats (200-220 g)Dosage:25, 50, 100 mg/kg Administration:I.p. 2 hours after the onset of ischemia Result:Reduced the neurological de?cit score.Suppressed the expression of NF-κB, TLR4 and IκBαin ischemic penumbra cortex, and inhibited the degradation of IκBα.Decreased the expressions of ICAM-1, COX-2, and iNOS.Downregulated downstream in?ammatory factor PGE2 and TNF-α expression.Decreased IL-1β, IL-6, IL-8, and IL-10 protein expression.

Ginkgetin

Endocrinology/Hormones

CaMK

STAT3

Inflammation/Immunology

——

481-46-9

566.51

C32H22O10

>98% (HPLC)

DMSO : ≥ 83.3 mg/mL; 147.04 mM

COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OC)O)C4=C(C=C(C5=C4OC(=CC5=O)C6=CC=C(C=C6)O)O)O

5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

(-20℃)

With Ice Pack

≥ 2 years