SSE15206

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SSE15206是一种克服多药耐药性的微管聚合抑制剂。由于癌细胞中纺锤体形成不完整，导致异常有丝分裂，导致 G2/M 期停滞。

SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.

SSE15206 induces apoptosis in cells irrespective of MDR-1 overexpression cell lines (KB-V1, A2780-Pac-Res), highly resistant to paclitaxel cells (HCT116-Pac-Res) and parental cells at the concentration of 5 × and 10 × GI50 values. To conclude, SSE15206 is able to overcome resistance to chemotherapeutic drugs such as paclitaxel in different cancer cell lines. Western Blot Analysis Cell Line:Drug-resistant cell lines (KB-V1, A2780-Pac-Res, HCT116-Pac-Res) and parental cells. Concentration:5 × and 10 × GI50 values (GI50=197 nM in HCT-116 cells).Incubation Time:24 hours.Result:Induced apoptosis in cells irrespective of MDR-1 overexpression and HCT116-Pac-Res and parental cells.

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Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

microtubule

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1370046-40-4

371.45

C19H21N3O3S?

>98% (HPLC)

DMSO:150 mg/mL (403.82 mM)

COc1cc(cc(OC)c1OC)C1CC(=NN1C(N)=S)c1ccccc1

45-Dihydro-3-phenyl-5-(345-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide

(-20℃)

With Ice Pack

≥ 2 years