021-51111890
购物车（0）
sales@molnova.cn
SR-12813
CAS No. 126411-39-0
SR-12813 ( GW 485801 )
产品货号. M17918 CAS No. 126411-39-0
SR-12813 是一种孕烷 X 受体 (PXR) 激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥405 | 有现货 |
|
| 10MG | ￥551 | 有现货 |
|
| 25MG | ￥1166 | 有现货 |
|
| 50MG | ￥1968 | 有现货 |
|
| 100MG | ￥2843 | 有现货 |
|
| 200MG | ￥4593 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称SR-12813
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述SR-12813 是一种孕烷 X 受体 (PXR) 激动剂。
-
产品描述SR-12813 is a pregnane X receptor (PXR) agonist.
-
体外实验SR-12813 inhibits incorporation of tritiated water into cholesterol with an IC50 of 1.2 μM but has no effect on fatty acid synthesis. Furthermore, SR-12813 reduces cellular 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity with an IC50 of 0.85 μM. Both 25-HC and SR-12813 can kill mammalian cells through blocking the synthesis of cholesterol, thereby they are ideal regents for lethal selection. SR-12813 kills HeLa cells at concentration range from 8 μM to 16 μM. SR-12813 kills wild type cells and mutant cells infected by Ad-Cre (SL-5+Cre), but the mutant SL-5 survives this condition. SR-12813 or 25-HC promotes the degradation of the 95-KDa full-length HMG-CoA reductase in wild type HeLa and SL-5 mutant cells.
-
体内实验——
-
同义词GW 485801
-
通路Membrane Transporter/Ion Channel
-
靶点Carbonic Anhydrase
-
受体HMG-CoA reductase
-
研究领域Metabolic Disease
-
适应症——
化学信息
-
CAS Number126411-39-0
-
分子量504.53
-
分子式C24H42O7P2
-
纯度>98% (HPLC)
-
溶解度DMSO : ≥ 50 mg/mL; 99.10 mM
-
SMILESCCOP(=O)(OCC)C(=CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C)P(=O)(OCC)OCC
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
产品手册
关联产品
-
Brinzolamide
布林佐胺是一种高度特异性、非竞争性、可逆碳酸酐酶抑制剂。
-
(Iso)-Samixogrel
(Iso)-Samixogrel shows activity against Carbonic anhydrase and Cyclooxygenase 2.
-
Histone acetyltransf...
Histone acetyltransferase p300 Inhibitor 4c is a 2-aminothiazole derivative. Histone acetyltransferase p300 Inhibitor 4c inhibited hCA I, hCA II, AChE and BChE with Ki values of 0.008 ± 0.001, 0.124 ± 0.017, 0.129 ± 0.030 and 0.083 ± 0.041 μM. 0.017, 0.129 ± 0.030 and 0.083 ± 0.041 μM.
