SNAP-94847

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SNAP-94847 是一种选择性竞争性 MCH1 受体 (MCH1-R) 拮抗剂 (Ki: 2.2 nM)。它具有抗焦虑和抗抑郁活性，并能减少小鼠的食物摄入量。

SNAP-94847 is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces food intake in mice.

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SNAP 94847 (oral gavage; 20?mg/kg; 14 days) shows an exaggerated locomotor response to acute quinpirole [treatment:?F(2,19)=11.31,?treatment?×?time:?F(34,323)?=?4.061], the effect of SNAP 94847 on quinpirole-evoked ambulations over the entire observation period is significant compared to the untreated animals.SNAP 94847 (oral administration; 20?mg/kg; 21 days) in drink water, produces a significant increase in ambulation relative to untreated animals [treatment:?F(3,28)?=?8.971; treatment?×?time:?F(51,476)=11.50]. shows a marked increase in locomotion is apparent after 40?min in the SNAP 94847-treated group,this effect is significant over 180?min.SNAP 94847 (oral administration; 10?mg/kg), has a good bioavailability (59%), low plasma and blood clearances of 4.2 L/hr/kg and 3.3 L/hr/kg, respectively, and the half-life was shown to be 5.2 h in rats in a PK study. Animal Model:Rat Dosage:20?mg/kg Administration:Oral administration; 20?mg/kg; 14 days Result:Exhibited a exaggerated locomotor response to acute quinpirole.Animal Model:Rat (PK study)Dosage:10 mg/kg Administration:oral gavage; 10 mg/kg Result:Exhibited good physicochemical properties in rats.

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GPCR/G Protein

MCHR

MCH1-R

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487051-12-7

478.57

C29H32F2N2O2

>98% (HPLC)

DMSO: 20 mg/mL (41.79 mM)

Cl.CC(C)C(=O)Nc1ccc(C)c(c1)C1CCN(Cc2ccc(Oc3ccc(F)c(F)c3)cc2)CC1

N-(3-{1-[4-(34-Difluorophenoxy)benzyl]-4-piperidinyl}-4-methylphenyl)-2-methylpropanamide

(-20℃)

With Ice Pack

≥ 2 years