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SKI-178
CAS No. 1259484-97-3
SKI-178 ( —— )
产品货号. M23431 CAS No. 1259484-97-3
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM.?
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥332 | 有现货 |
|
| 5MG | ￥535 | 有现货 |
|
| 10MG | ￥940 | 有现货 |
|
| 25MG | ￥1831 | 有现货 |
|
| 50MG | ￥2940 | 有现货 |
|
| 100MG | ￥4431 | 有现货 |
|
| 500MG | ￥9477 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SKI-178
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM.?
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产品描述SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM.?It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade.?The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.?
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同义词——
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis;SphK1;SphK2
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研究领域——
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适应症——
化学信息
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CAS Number1259484-97-3
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分子量394.4
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分子式C21H22N4O4
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纯度>98% (HPLC)
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溶解度DMSO:50 mg/mL?(126.77 mM;?Need ultrasonic)
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SMILESO=C(C1=CC(C2=CC=C(OC)C=C2)=NN1)N/N=C(C3=CC=C(OC)C(OC)=C3)\C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Hengst JA, et al. SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models. Cancer Transl Med. 2017;3(4):109-121.
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