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SJB3-019A

CAS No. ——

SJB3-019A ( —— )

产品货号. M17002 CAS No. ——

A novel potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
10MG ¥2434 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    SJB3-019A
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A novel potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM.
  • 产品描述
    A novel potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells; also increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity; triggers apoptosis in multiple myeloma cells via activation of caspase-3/8/9, degrades USP1 and downstream inhibitor of DNA-binding proteins as well as inhibits DNA repair via blockade of Fanconi anemia pathway and homologous recombination; downregulates multiple myeloma stem cell Notch-1, Notch-2, SOX-4, and SOX-2, and induces generation of more mature and differentiated plasma cells.
  • 同义词
    ——
  • 通路
    Proteasome/Ubiquitin
  • 靶点
    DUB
  • 受体
    DUB
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    ——
  • 分子量
    276.25
  • 分子式
    C16H8N2O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    10 mM in DMSO
  • SMILES
    ——
  • 化学全称
    2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Mistry H, et al. Mol Cancer Ther. 2013 Dec;12(12):2651-62.
2. Das DS, et al. Clin Cancer Res. 2017 Mar 7. doi: 10.1158/1078-0432.CCR-16-2692.
产品手册
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