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SJB3-019A
CAS No. ——
SJB3-019A ( —— )
产品货号. M17002 CAS No. ——
一种新型有效的泛素特异性蛋白酶 USP1 抑制剂，IC50 为 78.1 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥2434 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SJB3-019A
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种新型有效的泛素特异性蛋白酶 USP1 抑制剂，IC50 为 78.1 nM。
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产品描述A novel potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells; also increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity; triggers apoptosis in multiple myeloma cells via activation of caspase-3/8/9, degrades USP1 and downstream inhibitor of DNA-binding proteins as well as inhibits DNA repair via blockade of Fanconi anemia pathway and homologous recombination; downregulates multiple myeloma stem cell Notch-1, Notch-2, SOX-4, and SOX-2, and induces generation of more mature and differentiated plasma cells.
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体外实验——
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体内实验——
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同义词——
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通路Proteasome/Ubiquitin
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靶点DUB
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受体DUB
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量276.2463
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分子式C16H8N2O3
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILES——
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化学全称2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mistry H, et al. Mol Cancer Ther. 2013 Dec;12(12):2651-62.
2. Das DS, et al. Clin Cancer Res. 2017 Mar 7. doi: 10.1158/1078-0432.CCR-16-2692.
