SIRT-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SIRT-IN-1 是一种有效的 SIRT1/2/3 抑制剂（IC50 分别为 15、10、33 μM）。

SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).(In Vitro):SIRT-IN-1 is one of the most potent inhibitor of truncated pan SIRT1/ 2/3(IC50 values are 0.015, 0.010, 0.033 μM, respectively). SIRT-IN-1 binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel.

SIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel.

——

——

Chromatin/Epigenetic

Sirtuin

KRas G12C

——

——

1431411-60-7

389.52

C19H27N5O2S

>98% (HPLC)

In Vitro:?DMSO : 19.23 mg/mL (49.37 mM)

CC(C)(C)C(=O)NCCC1CCN(CC1)c1ncnc2cc(sc12)C(N)=O

——

(-20℃)

With Ice Pack

≥ 2 years