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SIB-1757
CAS No. 31993-01-8
SIB-1757 ( 6-methyl-2-[(E)-phenyldiazenyl]pyridin-3 )
产品货号. M21962 CAS No. 31993-01-8
SIB-1757 是 mGlu5 代谢型谷氨酸受体亚型的选择性拮抗剂（hmGlu5，IC50：0.4 μM），SIB-1757 通过鞘内 (i.th.)、皮下 (sc) 或足底内 (i.pl.) 注射给药。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥599 | 有现货 |
|
| 5MG | ￥988 | 有现货 |
|
| 10MG | ￥1482 | 有现货 |
|
| 25MG | ￥2657 | 有现货 |
|
| 50MG | ￥3872 | 有现货 |
|
| 100MG | ￥5370 | 有现货 |
|
| 500MG | ￥11097 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SIB-1757
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SIB-1757 是 mGlu5 代谢型谷氨酸受体亚型的选择性拮抗剂（hmGlu5，IC50：0.4 μM），SIB-1757 通过鞘内 (i.th.)、皮下 (sc) 或足底内 (i.pl.) 注射给药。
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产品描述SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM).SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.?In SNL rats, i.th.?SIB-1757 produced a partial reversal of tactile allodynia with a shallow dose-response curve ranging over three-orders of magnitude;?SIB-1757 was inactive against allodynia when given systemically.?SIB-1757 produced full reversal of thermal hyperalgesia in SNL rats following administration either spinally or locally to the injured paw;?administration to the contralateral paw had no effect.?SIB-1757 did not produce antinociception in either the SNL or sham-operated rats by any route.
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体外实验——
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体内实验——
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同义词6-methyl-2-[(E)-phenyldiazenyl]pyridin-3
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通路Neuroscience
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靶点GluR
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受体mGluR5
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研究领域——
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适应症——
化学信息
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CAS Number31993-01-8
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分子量213.24
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分子式C12H11N3O
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纯度>98% (HPLC)
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溶解度DMSO:17 mg/ml(79.72 mM)
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SMILESCc1ccc(O)c(n1)\N=N\c1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Dogrul A , Ossipov M H , Lai J , et al. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR5) antagonist, in experimental neuropathic pain in rats[J]. 2000, 292(2):0-118.2. Varney M A A , Cosford N D P , Jachec C , et al. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5[J]. Journal of Pharmacology & Experimental Therapeutics, 1999, 290(1):170-181.
产品手册
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