021-51111890
购物车（）
sales@molnova.cn
SGC-iMLLT
CAS No.
SGC-iMLLT ( —— )
产品货号. M17063 CAS No.
SGC-iMLLT is the first small molecule chemical probe for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
生物学信息
-
产品名称SGC-iMLLT
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述SGC-iMLLT is the first small molecule chemical probe for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively.
-
产品描述SGC-iMLLT is the first small molecule chemical probe for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively, IC50 of 0.26 uM (MLLT1); SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interaction; dsiplays excellent selectivity over other human YD proteins (YEATS2/4) and bromodomains.
-
同义词——
-
通路Chromatin/Epigenetic
-
靶点Bromodomain
-
受体Bromodomain
-
研究领域——
-
适应症——
化学信息
-
CAS Number--
-
分子量388.48
-
分子式C22H24N6O
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESO=C(C1=CC2=C(N(C)N=C2)C=C1)NC3=CC=C4NC(CN5[C@@H](C)CCC5)=NC4=C3
-
化学全称(S)-1-methyl-N-(2-((2-methylpyrrolidin-1-yl)methyl)-1H-benzo[d]imidazol-5-yl)-1H-indazole-5-carboxamide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Moustakim M, et al. Angew Chem Int Ed Engl. 2018 Oct 5. doi: 10.1002/anie.201810617.
